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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

Search for IM-22124

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Interaction Network

Legend

Nodes

Color ~ Species

Homo sapiens

Shape ~ Type

protein

Edges

Color ~ MI Score

Width ~ #Evidence

Showing 1 to 4 of 4 entries

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Select	Molecule A	Molecule B	Identifier A	Identifier B	Type A	Type B	Species A	Species B	Host Organism	Positive interaction	Detection Method	Publication IDs	Interaction Type	Interaction AC	Confidence Value	Expansion Method	Aliases A	Aliases B	Feature count	Interaction Annotations

Select	Molecule A	Molecule B	Identifier A	Identifier B	Type A	Type B	Species A	Species B	Host Organism	Positive interaction	Detection Method	Publication IDs	Interaction Type	Interaction AC	Confidence Value	Expansion Method	Aliases A	Aliases B	Feature count	Interaction Annotations
Show details of EBI-9032923	ADAMTS12	COMP	UniProt P58397	UniProt P49747	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	protease assay	18485748	protein cleavage	EBI-9032923	MI Score:0.68		orf name UNQ1918/PRO4389 gene name ADAMTS12	gene name synonym Thrombospondin-5 gene name COMP	0	inhibition P01023 comment Inhibitory effect of alpha2M is concentration-dependent causality statement P58397 increases degradation at protein level of P49747 figure legend Fig 1 and 6B
Show details of EBI-9028352	A2M	ADAMTS12	UniProt P01023	UniProt P58397	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	protease assay	18485748	protein cleavage	EBI-9028352	MI Score:0.44		gene name A2M orf name FWP007 gene name synonym C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 gene name synonym CPAMD5	orf name UNQ1918/PRO4389 gene name ADAMTS12	0	inhibition P01023 causality statement P58397 increases degradation of protein level of P01023 comment Inhibitory effect of alpha2M is concentration-dependent figure legend Fig 4C and 6A
Show details of EBI-9028344	A2M	ADAMTS7	UniProt P01023	UniProt Q9UKP4	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	protease assay	18485748	protein cleavage	EBI-9028344	MI Score:0.44		gene name A2M orf name FWP007 gene name synonym C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 gene name synonym CPAMD5	gene name synonym COMPase gene name Adamts7	0	inhibition P01023 comment Inhibitory effect of alpha2M is concentration-dependent figure legend Fig 4A and B and 5A causality statement Q9UKP4 increases degradation at protein level of P01023
Show details of EBI-9032726	ADAMTS7	COMP	UniProt Q9UKP4	UniProt P49747	protein	protein	Homo sapiens	Homo sapiens	In vitro	✔️	protease assay	18485748	protein cleavage	EBI-9032726	MI Score:0.44		gene name synonym COMPase gene name Adamts7	gene name synonym Thrombospondin-5 gene name COMP	0	causality statement Q9UKP4 increases degradation at protein level of P49747 inhibition P01023 figure legend Fig 1 and 5B comment Inhibitory effect of alpha2M is concentration-dependent

Showing 1 to 4 of 4 entries

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Showing 1 to 4 of 4 entries

Select	Accession	Name	Preferred ID	Type	Species	Description	Alias	Alternative IDs	Interactions found in current search	Total interactions in all IntAct
	EBI-9028319	ADAMTS7	UniProt Q9UKP4	protein	Homo sapiens	A disintegrin and metalloproteinase with thrombospondin motifs 7	gene name synonym COMPase gene name Adamts7	UniProt3 Q9UKP4 Q14F51 Q6P7J9 Ensembl1 ENSP00000373472.4 IntAct1 EBI-9028319	2	58
	EBI-2531022	COMP	UniProt P49747	protein	Homo sapiens	Cartilage oligomeric matrix protein	gene name synonym Thrombospondin-5 gene name COMP	UniProt7 Q16389 B4DKJ3 Q8N4T2 O14592 P49747 Q2NL86 Q16388 IntAct1 EBI-2531022 Ensembl1 ENSP00000222271.2	2	47
	EBI-9028051	ADAMTS12	UniProt P58397	protein	Homo sapiens	A disintegrin and metalloproteinase with thrombospondin motifs 12	orf name UNQ1918/PRO4389 gene name ADAMTS12	UniProt4 P58397 A5D6V6 Q6UWL3 A2RRN9 IntAct1 EBI-9028051 Ensembl1 ENSP00000422554.1	2	70
	EBI-640741	A2M	UniProt P01023	protein	Homo sapiens	Alpha-2-macroglobulin	gene name A2M orf name FWP007 gene name synonym C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 gene name synonym CPAMD5	UniProt7 P01023 Q6PIY3 Q68DN2 Q6PN97 Q5QTS0 Q59F47 Q13677 IntAct1 EBI-640741 Ensembl1 ENSP00000323929.8	2	371

Showing 1 to 4 of 4 entries